Note that this is a change in nomenclature, which is aligned with the World Health Organization decision, and does not represent a change in the listed agent. Modified Venezuelan Equine Encephalitis Virus TC-83(A3G) strain is a select agent. zeae, provided that the individual or entity can identify that the agent is within the exclusion category. Select agents or toxins that meet any of the following criteria are excluded from the requirements of this part: Any subspecies of Ralstonia solanacearum except race 3, biovar 2 and all subspecies of Sclerophthora rayssiae except var. For determining the regulatory status of Recombinant and/or Synthetic nucleic acids that encode for the toxic form(s) of any select toxins if the nucleic acids (i) can be expressed in vivo or in vitro, or (ii) are in a vector or recombinant host genome and can be expressed in vivo or in vitro please reference guidance here. For determining the regulatory status of nucleic acids that are capable of producing infectious forms of select agent viruses, please reference guidance here. Select agents that meet any of the following criteria are excluded from the requirements of this part: Any low pathogenic strains of avian influenza virus, South American genotype of eastern equine encephalitis virus, west African clade of Mpox viruses, any strain of Newcastle disease virus which does not meet the criteria for virulent Newcastle disease virus, all subspecies Mycoplasma capricolum except subspecies capripneumoniae (contagious caprine pleuropneumonia), all subspecies Mycoplasma mycoides except subspecies mycoides small colony (Mmm SC) (contagious bovine pleuropneumonia), and any subtypes of Venezuelan equine encephalitis virus except for Subtypes IAB or IC, provided that the individual or entity can verify that the agent is within the exclusion category. A failure to detect a cleavage site that is consistent with virulent strains does not confirm the absence of a virulent virus. A virulent Newcastle disease virus (avian paramyxovirus serotype 1) has an intracerebral pathogenicity index in day-old chicks (Gallus gallus) of 0.7 or greater or has an amino acid sequence at the fusion (F) protein cleavage site that is consistent with virulent strains of Newcastle disease virus. C = Cysteine residues are all present as disulfides, with the 1st and 3rd Cysteine, and the 2nd and 4th Cysteine forming specific disulfide bridges The consensus sequence includes known toxins a-MI and a-GI (shown above) as well as a-GIA, Ac1.1a, a-CnIA, a-CnIB X1 = any amino acid(s) or Des-X X2 = Asparagine or Histidine P = Proline A = Alanine G = Glycine X3 = Arginine or Lysine X4 = Asparagine, Histidine, Lysine, Arginine, Tyrosine, Phenylalanine or Tryptophan X5 = Tyrosine, Phenylalanine, or Tryptophan X6 = Serine, Threonine, Glutamate, Aspartate, Glutamine, or Asparagine X7 = Any amino acid(s) or Des X and “Des X” = “an amino acid does not have to be present at this position.” For example if a peptide sequence were XCCHPA then the related peptide CCHPA would be designated as Des-X. (formerly Phoma glycinicola and Pyrenochaeta glycines) USDA Plant Protection And Quarantine (PPQ) Tick-borne encephalitis complex (flavi) viruses: Staphylococcal enterotoxins (subtypes A,B,C,D,E).South American Haemorrhagic Fever viruses:
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